A04AA02 - Granisetron |
Probably Not Porphyrinogenic |
PNP |
Rationale
Substrate for CYPs 3A4 and 3A5. No data pointing to clinical CYP-induction.
Chemical description
Selective 5-HT-antagonist used as prophylaxis or treatment of postoperative nausea and nausea under chemotherapy, 2-9 mg/d perorally or parenterally. Metabolized mainly by CYP3A4. No instances of CYP-induction observed clinically.
Ipnet drug reports
Uneventful use reported in 2 patients with acute porphyria.
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References
| # | Citation details | PubMed ID |
|---|---|---|
| Porphyria Drug Lists | ||
| 1. | French List
Centre Français des Porphyries
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Tradenames
Sancuso · Sustol 
Granicip · Grantryl · Kytril 
Granisetron · Kytril · Sancuso 
Granisetron · Kytril · Sancuso 
Kytril 
Granisetron · Kytril · Sancuso 
Granegis · Granigen · Granisetron · Sancuso 
Grandise · Granem · Granisetron · Kytril · Pandiol · Sancuso 
Granisetron · Granored · Sancuso 
Granisetron · Kytril 
Granisetron · Kytril · Sancuso 
Granisetron · Granisym · Sancuso 
Granisetron · Kytril · Sancuso 
Granisetron · Sancuso 
Sancuso 
Granirex · Granisetron 
Emenat · Granisetron · Granodex · Kytril 
Granisetron 
Sancuso 
Kytril · Sancuso 
Granem · Sancuso 
Gazoron · Granisetron · Granisym · Sancuso 
Granisetron · Sancuso 
Sancuso 
Granisetron · Kytril · Sancuso 
Kytril · Rasetron 
Granizetron · Sancuso 
Granisetron · Kytril · Rasetron · Sancuso 
Granegis · Granisetron · Kytril · Sancuso 
Kytril · Sancuso · Sustol 
Granisetron